Christopher J. Drake, Ph.D.
Professor

Room 626, Basic Science Building
Office: (843) 792-1692
Lab: (843) 792-6587

Email: drakec@musc.edu

Education:

BA History Jacksonville Univ. 1969
BA Biology Univ. of Massachusetts 1977
PhD Cell Biology Medical University of South Carolina 1995

Research Activity:

Molecular and cellular interactions in blood vessel development.

Recent Publications:

1.  Mironov V, Visconti RP, Kasyanov V, Forgacs G, Drake CJ, Markwald RR. Organ printing: tissue spheroids as building blocks.  Biomaterials. 2009 Apr;30(12):2164-74. Epub 2009 Jan 26. Review.
2. Mironov V, Kasyanov V, Drake C, Markwald RR. Organ printing: promises and challenges.  Regen Med. 2008 Jan;3(1):93-103.
3. Mironov V, Drake C, Wen X. Research project: Charleston Bioengineered Kidney Project.  Biotechnol J. 2006 Sep;1(9):903-5.
4. Larue, A.C., Masuya, M., Ebihara, Y., Fleming, P.A., Visconti, R.P., Minamiguchi, H., Ogawa, M., Drake, C.J. Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated  with solid tumors. Exp Hematol. 2006; 34(2): 208-18. PMID:16459189.
   
5. Ebihara, Y., Masuya, M., Larue, A.C., Fleming, P.A., Visconti, R.P., Minamiguchi, H., Drake, C.J., Ogawa, M. Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes. Exp Hematol. 2006; 34(2): 219-29. PMID:16459190.
   
6.  Ogawa, M., LaRue ,A.C., Drake, C.J. Hematopoietic Origin of Fibroblasts/Myofibroblasts Its Patho-physiological Implications. Blood 2006;108(9):2893-6. PMID:16840726.
   
7. Visconti, R.P., Ebihara, Y., Larue, A.C., Fleming, P.A., McQuinn, T.C., Masuya, M., Minamiguchi, H., Markwald, R.R., Ogawa, M., Drake, C.J. An In Vivo Analysis of Hematopoietic Stem Cell Potential. Hematopoietic Origin of Cardiac Valve Interstitial Cells. Circ Res. 2006; 17;98(5): 690-6. PMID:16456103.
   
8.  Drake, C.J., Fleming, P.A., Argraves, W.S. The Genetics of Vasculogenesis. Novartis Foundation symposium: Vascular Development 2007; 238:61-76. PMID: 18300414  
   
9. Gentile, C., Fleming, P.A., Mironov, V., Argraves, K.M., Argraves, W.S., Drake, C.J. VEGF-mediated fusion in the generation of uniluminal vascular spheroids. Dev Dyn. 2008; 237(10):2918-25. PMID: 18816835.
   
10. Mironov V., Kasyanov V., Drake C.J., Markwald R.R. Organ printing: promises and challenges. Regen Med. 2008; 3(1):93-103. PMID: 18154465.
    
11. Mironov, V., Visconti, R.P., Kasyanov, V., Forgacs, G., Drake, C.J., Markwald, R.R. Organ printing: tissue spheroids as building blocks. Biomaterials. 2009; 30(12):2164-2174. PMID:19176247.
    
12. Fleming, P.A, Argraves W.S., Gentile C., Neagu A., Forgacs G., Drake C.J. Fusion of uniluminal vascular spheroids: A model for assembly of blood vessels. Dev Dyn. 2010;239:398406.  PMID: 19918756.
    
13. Hajdu, Z., Stephen J. Romeo, S.J., Fleming, P.A., Markwald R.R., Visconti, R.P., Drake, C.J. Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process. J Mol Cell Cardiol. 2011; Dec;51(6):955-65. Epub 2011 Aug 16. PMID:21871458
14. Ogawa M, LaRue AC, Drake CJ. Hematopoietic origin of fibroblasts/myofibroblasts: Its pathophysiologic implications. Blood. 2006 Nov 1;108(9):2893-6. Epub 2006 Jul 13.
15. Smith BT, Mussell JC, Fleming PA, Barth JL, Spyropoulos DD, Cooley MA, Drake CJ, Argraves WS. Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation. BMC Dev Biol. 2006 Jun 20;6:30.
16. Drake CJ, Wessels A, Trusk T, Little CD. Elevated vascular endothelial cell growth factor affects mesocardial morphogenesis and inhibits normal heart bending. Dev Dyn. 2006 May 4;235(1):spc1 [Epub ahead of print]
17. Ebihara Y, Masuya M, Larue AC, Fleming PA, Visconti RP, Minamiguchi H, Drake CJ, Ogawa M. Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes. Exp Hematol. 2006 Feb;34(2):219-29.
18. LaRue AC, Masuya M, Ebihara Y, Fleming PA, Visconti RP, Minamiguchi H, Ogawa M, Drake CJ. Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated with solid tumors. Exp Hematol. 2006 Feb;34(2):208-18.
19. Visconti RP, Ebihara Y, LaRue AC, Fleming PA, McQuinn TC, Masuya M, Minamiguchi H, Markwald RR, Ogawa M, Drake CJ. An in vivo analysis of hematopoietic stem cell potential: hematopoietic origin of cardiac valve interstitial cells. Circ Res. 2006 Mar 17;98(5):690-6. Epub 2006 Feb 2.
20. Drake CJ, Wessels A, Trusk T, Little CD. Elevated vascular endothelial cell growth factor affects mesocardial morphogenesis and inhibits normal heart bending. Dev Dyn. 2006 Jan;235(1):10-8.
21. Abe T, Fleming PA, Masuya M, Minamiguchi H, Ebihara Y, Drake CJ, Ogawaa M. Granulocyte/macrophage origin of glomerular mesangial cells. Int J Hematol. 2005 Aug;82(2):115-8.
22. Argraves WS, Drake CJ. Genes critical to vasculogenesis as defined by systematic analysis of vascular defects in knockout mice. Anat Rec A Discov Mol Cell Evol Biol. 2005 Oct;286(2):875-84.
23. Anderson-Berry A, O'Brien EA, Bleyl SB, Lawson A, Gundersen N, Ryssman D, Sweeley J, Dahl MJ, Drake CJ, Schoenwolf GC, Albertine KH. Vasculogenesis drives pulmonary vascular growth in the developing chick embryo. Dev Dyn. 2005 May;233(1):145-53.