Department of Regenerative Medicine and Cell biology

Edward L. Krug, Ph.D.
Associate Professor

Departmental Mentoring Champion
Assistant Dean for Postdoctoral Affairs


Room 101, BioEngineering Building
Office: (843) 876-2404
FAX: (843) 876-2416


Email: krugel@musc.edu

Education:

BS Biology Indiana State Univ. 1974
MS Biochemistry Purdue University 1977
PhD Biochemistry Purdue University 1983
Postdoctoral Fellow at Texas Tech Univ. and Medical College of Wisconsin

Research Interests:

Biochemical and molecular characterization of extracellular matrix proteins that direct early morphogenetic events

Recent Publications:

  1. Lang, H, M Li, LA Kilpatrick, J Zhu, DJ Samuvel, EL Krug, and JC Goddard (2011). Sox2 up-regulation and glial cell proliferation following degeneration of spinalganglion neurons in the adult mouse inner ear. J Assoc Res Otolaryngol 12:151-171.
  2. Grey, AC, AK Gelasco, J Section, RA Moreno-Rodriguez, EL KRUG, and KL Schey (2010). Molecular morphology of the chick heart visualized by MALDI imaging mass spectrometry. Anat Rec 293:821-828.
  3. Schwacke, JH, EG Hill, EL KRUG, S Comte-Walters, and KL Schey (2009). iQuantitator: A tool for protein expression inference using iTRAQ. BMC Bioinformatics 10:342
  4. Mishima N, Hoffman S, Hill EG, Krug EL. Chick embryos exposed to trichloroethylene in an ex ovo culture model show selective defects in early endocardial cushion tissue formation. Birth Defects Res A Clin Mol Teratol. 2006 Jul;76(7):517-27.
  5. Moreno-Rodriguez RA, Krug EL, Reyes L, Villavicencio L, Mjaatvedt CH, Markwald RR. Bidirectional fusion of the heart-forming fields in the developing chick embryo. Dev Dyn. 2006 Jan;235(1):191-202.
  6. Almeida JS, Stanislaus R, Krug E, Arthur JM (2005). Normalization and analysis of residual variation in two-dimensional gel electrophoresis for quantitative differential proteomics. Proteomics 5: 1242-1249.
  7. Kern CB, Hoffman S, Moreno R, Damon BJ, Norris RA, Krug EL, Markwald RR, Mjaatvedt CH. Immunolocalization of chick periostin protein in the developing heart. Anat Rec A Discov Mol Cell Evol Biol. 2005 May;284(1):415-23.
  8. de la Cruz MV, Markwald RR, Krug EL, Rumenoff L, Sanchez Gomez C, Sadowinski S, Galicia TD, Gomez F, Salazar Garcia M, Villavicencio Guzman L, Reyes Angeles L, Moreno-Rodriguez RA. Living morphogenesis of the ventricles and congenital pathology of their component parts. Cardiol Young. 2001 Nov;11(6):588-600. Review.
  9. Bianchi LM, Liu H, Krug EL, Capehart AA. Selective and transient expression of a native chondroitin sulfate epitope in Deiters' cells, pillar cells, and the developing tectorial membrane. Anat Rec. 1999 Sep 1;256(1):64-71.
  10. Capehart AA, Mjaatvedt CH, Hoffman S, Krug EL. Dynamic expression of a native chondroitin sulfate epitope reveals microheterogeneity of extracellular matrix organization in the embryonic chick heart. Anat Rec. 1999 Feb 1;254(2):181-95.
  11. Nakajima Y, Yamagishi T, Nakamura H, Markwald RR, Krug EL. An autocrine function for transforming growth factor beta 3 in the atrioventricular endocardial cushion tissue formation during chick heart development. Ann N Y Acad Sci. 1998 Oct 23;857:272-5.
  12. Nakajima Y, Yamagishi T, Nakamura H, Markwald RR, Krug EL. An autocrine function for transforming growth factor (TGF)-beta3 in the transformation of atrioventricular canal endocardium into mesenchyme during chick heart development. Dev Biol. 1998 Feb 1;194(1):99-113.
  13. Capehart AA, Wienecke MM, Kitten GT, Solursh M, Krug EL. Production of a monoclonal antibody by in vitro immunization that recognizes a native chondroitin sulfate epitope in the embryonic chick limb and heart. J Histochem Cytochem. 1997 Nov;45(11):1567-81.
  14. Moreno-Rodriguez RA, de la Cruz MV, Krug EL. Temporal and spatial asymmetries in the initial distribution of mesenchyme cells in the atrioventricular canal cushions of the developing chick heart. Anat Rec. 1997 May;248(1):84-92.

 

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