Department of Regenerative Medicine and Cell biology

Roger R. Markwald, Ph.D.
Professor and Chair


Room 613, Children's Research Institute
Office: (843) 792-5628
Lab: (843) 792-7928

Email: markwald@musc.edu

Education:

BA Biology/Chemistry California St. Polytechnic Univ. 1965
MS Anatomy Colorado State University 1968
PhD Anatomy Colorado State University 1969
Postdoctoral work at Medical University of South Carolina

Research Interests: 

Heart Development and Regenerative Medicine

Recent Publications: (Journal Article List)

  1. Ma Z, Liu Q, Yang H, Runyan RB, Eisenberg CA, Xu M, Borg TK, Markwald R, Wang Y & Gao BZ. Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level. Light Sci Appl 2013 2: [PMID: 24527266].
  2. Ghatak S, Misra S, Norris RA, Rodriquez RM, Hoffman S, Levine RA, Hascall VC & Markwald RR. Periostin induces intracellular cross talk between kinases and hyaluronan in atrioventricular valvulogenesis. J Biol Chem 2014 [PMID: 24469446].
  3. Ghatak S, Bogatkevich GS, Atanelishvili I, Akter T, Feghali-Bostwick CA, Hoffman S, Fresco VM, Fuchs JC, Visconti RP, Markwald RR, Padhye SB, Silver RM, Hascall VC & Misra S. Overexpression of c-Met and CD44v6 receptors contributes to autocrine TGF beta1 signaling in interstitial lung disease. J Biol Chem 2013 [PMID: 24324260].
  4. Ghatak S, Vyas A, Misra S, O'Brien P, Zambre A, Fresco VM, Markwald RR, Swamy KV, Afrasiabi Z, Choudhury A, Khetmalas M & Padhye S. Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities. Bioorg Med Chem Lett 2014 24: 317-324 [PMID: 24295787].
  5. Duval D, Lardeux A, Le Tourneau T, Norris RA, Markwald RR, Sauzeau V, Probst V, Le Marec H, Levine R, Schott JJ & Merot J. Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation. Biochim Biophys Acta 2014 1843: 234-244 [PMID: 24200678].
  6. Conway SJ, Izuhara K, Kudo Y, Litvin J, Markwald R, Ouyang G, Arron JR, Holweg CT & Kudo A. The role of periostin in tissue remodeling across health and disease. Cell Mol Life Sci 2014 71: 1279-1288 [PMID: 24146092].
  7. Twal WO, Klatt SC, Harikrishnan K, Gerges E, Cooley MA, Trusk TC, Zhou B, Gabr MG, Shazly T, Lessner SM, Markwald RR & Argraves WS. Cellularized Microcarriers as Adhesive Building Blocks for Fabrication of Tubular Tissue Constructs. Ann Biomed Eng 2013 [PMID: 23943070].
  8. Wang W, Leigh Herran C, Coutris N, Huang Y, Mironov V & Markwald R. Methodology for the Evaluation of Double-Layered Microcapsule Formability Zone in Compound Nozzle Jetting Based on Growth Rate Ratio. J Fluids Eng 2013 135: 510011-510018 [PMID: 23904666].
  9. Kolpa HJ, Peal DS, Lynch SN, Giokas AC, Ghatak S, Misra S, Norris RA, Macrae CA, Markwald RR, Ellinor P, Bischoff J & Milan DJ. miR-21 represses Pdcd4 during cardiac valvulogenesis. Development 2013 140: 2172-2180 [PMID: 23578931].
  10. Markwald RR, Melanson EL, Smith MR, Higgins J, Perreault L, Eckel RH & Wright KP, Jr. Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proc Natl Acad Sci U S A 2013 110: 5695-5700 [PMID: 23479616].
  11. Ma Z, Yang H, Liu H, Xu M, Runyan RB, Eisenberg CA, Markwald RR, Borg TK & Gao BZ. Mesenchymal stem cell-cardiomyocyte interactions under defined contact modes on laser-patterned biochips. PLoS One 2013 8: e56554 [PMID: 23418583].
  12. Wu B, Zhang Z, Lui W, Chen X, Wang Y, Chamberlain AA, Moreno-Rodriguez RA, Markwald RR, O'Rourke BP, Sharp DJ, Zheng D, Lenz J, Baldwin HS, Chang CP & Zhou B. Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell 2012 151: 1083-1096 [PMID: 23178125].
  13. Ma Z, Liu Q, Liu H, Yang H, Yun JX, Xu M, Eisenberg CA, Borg TK, Markwald R & Gao BZ. Cardiogenic Regulation of Stem-Cell Electrical Properties in a Laser-Patterned Biochip. Cell Mol Bioeng 2012 5: 327-336 [PMID: 23139730].
  14. Liu H, Shao Y, Qin W, Runyan RB, Xu M, Ma Z, Borg TK, Markwald R & Gao BZ. Myosin filament assembly onto myofibrils in live neonatal cardiomyocytes observed by TPEF-SHG microscopy. Cardiovasc Res 2013 97: 262-270 [PMID: 23118131].
  15. Sauls K, de Vlaming A, Harris BS, Williams K, Wessels A, Levine RA, Slaugenhaupt SA, Goodwin RL, Pavone LM, Merot J, Schott JJ, Le Tourneau T, Dix T, Jesinkey S, Feng Y, Walsh C, Zhou B, Baldwin S, Markwald RR & Norris RA. Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res 2012 96: 109-119 [PMID: 22843703].
  16. Xu C, Chai W, Huang Y & Markwald RR. Scaffold-free inkjet printing of three-dimensional zigzag cellular tubes. Biotechnol Bioeng 2012 109: 3152-3160 [PMID: 22767299].
  17. de Vlaming A, Sauls K, Hajdu Z, Visconti RP, Mehesz AN, Levine RA, Slaugenhaupt SA, Hagege A, Chester AH, Markwald RR & Norris RA. Atrioventricular valve development: new perspectives on an old theme. Differentiation 2012 84: 103-116 [PMID: 22579502].

 

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