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Chip Norris

Russell A. Norris, Ph.D.
Assistant Professor


Room 606, Children's Research Institute
Office: (843) 792-1544


Email: norrisra@musc.edu

Education:

University of Cincinnati 1991-1995 Bachelors of Science (Biology)
Medical University of South Carolina 1995-2000 PhD (Molecular, Cellular and Pathobiology)
Medical University of South Carolina 2001-2006 Post Doctoral Research
Medical University of South Carolina 2007-Current Assistant Professor

Research Interests:

A primary focus of the Norris lab is to deal with basic questions in formation of the cardiac valves and pathological processes that result in valve disease. The overall design follows a “cycle of discovery” that begins with the clinical condition, identifies gene candidates, and explores their mechanism of action and susceptibility to rescue. Mechanistic studies in turn point to related pathways for further gene discovery. Through an international consortium of clinicians and scientists, our lab has contributed to identifying new genes that cause valve disease in humans. Our ongoing projects have defined that these genes play a crucial role during the development of the valves, essentially laying the blueprint for valve construction. Thus, we propose that inherited heart valve disease is caused by inborn errors in the development of this structure. By studying these disease genes we can gain an understanding for how the valve develops and why valve defects occur. Harnessed with this information, targeted therapeutics can be developed that may be of benefit to patients with valvular heart disease, thus allowing us to complete the “cycle of discovery”.

MVP figure

Recent Publications:

  1. Norris RA, Borg TK, Butcher JT, Markwald RR. Neonatal and Adult Cardiovascular Pathophysiological Remodeling and Repair: Developmental Role of Periostin. Ann N Y Acad Sci. 2008 Mar;1123:30-40
  2. Inai, K., Norris R. A., Hoffman, S., Markwald, R. R. and Sugi, Y. BMP-2 induces cell migration and periostin expression during atrioventricular valvulogenesis. Dev Biol. 2008 Mar 15;315(2):383-96. Epub 2007 Dec 31.
  3. Norris, R.A., Moreno-Rodriguez, R.A., Sugi, Y, Hoffman, S., Amos, J., Hart, M.H., Potts, J., Goodwin, R.L., Markwald, R.R. Periostin Regulates Atrioventricular Valve Maturation. Dev Biol. 2008 Apr 15;316(2):200-13. Epub 2008 Jan 17.
  4. Norris RA, Potts JD, Yost MJ, Junor L, Brooks T, Tan H, Hoffman S, Hart MM, Kern MJ, Damon B, Markwald RR, Goodwin RL Periostin Promotes A Fibroblastic Lineage Pathway In Atrioventricular Valve Progenitor Cells. Dev Dyn. 2009 May;238(5):1052-63.
  5. Li G, Jin R, Norris RA, Zhang L, Yu S, Wu F, Markwald RR, Nanda A, Conway SJ, Smyth SS, Granger DN Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway. Atherosclerosis. 2010 Feb;208(2):358-65.
  6. Norris RA, Moreno-Rodriguez R, Hoffman S, Markwald RR. The Many Facets of the Matricelluar Protein, Periostin During Cardiac Development, Remodeling, And Pathophysiology J Cell Commun Signal. 2009 Dec;3(3-4):275-86.
  7. Markwald RR, Norris RA, Moreno-Rodriguez R, Levine RA. Developmental Basis Of Adult
    Cardiovascular Diseases:  Valvular Heart Diseases. Ann N Y Acad Sci. 2010 Feb;1188:177-83.
  8. Robert A. Levine, Sue Slaugenhaupt, Albert Hagege, Xavier Jeunemaitre, Russell A. Norris, Roger R. Markwald, on behalf of the Leducq Mitral Consortium. Mitral Valve Prolapse: From Genes To New Therapies. The Exciting Potential of an International Network of Scientists and Clinicians.  Society for MVP Syndrome and on-line at www.mitralvalveprolapse.com (Nov 2009).
  9. Norris RA, Moreno-Rodriguez, R, Wessels, A, Merot, J, Hagege, A, Slaugenhaupt, S, Schott, JJ, Harris, BS, Williams, LK, Richards, A, Levine, RA, Markwald, RR. Expression Of The Familial Cardiac Valvular Dystrophy Gene, Filamin-A, During Heart Morphogenesis. Dev Dyn. 2010 Jul;239(7):2118-2726.
  10. Chiu, Y-N, Norris RA, Mahler G, Recknagel A, Butcher JT. Complementary and Redundant Roles for TGFβ, BMP, and VEGF in Embryonic Atrioventricular Remodeling: Natural Template for Heart Valve Tissue Engineering. Tissue Eng Part A. 2010 Nov;16(11):3375-83. Epub 2010 Jul 14.
  11. Teekakirikul P, Eminaga S, Toka O, Alcalai R, Wang L, Wakimoto H, Nayor M, Konno T, Gorham JM, Wolf CM, Kim JB, Schmitt JP, Molkentin JD, Norris RA, Tager AM, Hoffman SR, Markwald RR, Seidman CE, Seidman JG. Cardiac fibrosis, in hypertrophic cardiomyopathy, is mediated by non-myocyte proliferation and requires TGFβ. J. Clin Invest. 2010 Sep 1. pii: 42028. doi: 10.1172/JCI42028.
  12. Tan H, Junor L, Price RL, Norris RA, Potts JD, Goodwin RL. Expression and deposition of fibrous extracellular matrix proteins in cardiac valves during chick development. Microsc Microanal. 2011 Feb;17(1):91-100.
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Last Updated: November 1, 2011