Department of Regenerative Medicine and Cell Biology


Demetri Spyropoulos, Ph.D.
Assistant Professor of Molecular Structural Biology

Hollings Cancer Center
Office: (843) 792-1625



BS Chemistry University of Maryland 1981
PhD Biological Chemistry Harvard University 1989

Research Interests:

Lymphoid, breast, bladder, prostate, & colon cancer Mammary gland & male urogenital system development, and hematopoiesis

Recent Publications:

  1. Annalaura Mancia, Spyropoulos DD, McFee WE, Newton DA, Baatz JE. Cryopreservation and in vitro culture of primary cell types from lung tissue of a stranded pygmy sperm whale (Kogia breviceps).  Comp Biochem Physiol C Toxicol Pharmacol. 2012 Jan;155(1):136-42. Epub 2011 Apr 9.
  2. Moussa O, LaRue AC, Abangan RS Jr, Williams CR, Zhang XK, Masuya M, Gong YZ, Spyropoulos DD, Ogawa M, Gilkeson G, Watson DK. Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1.  Mol Cell Biol. 2010 Nov;30(21):5194-206. Epub 2010 Sep 7.
  3. Grek CL, Newton DA, Spyropoulos DD, Baatz JE. Hypoxia up-regulates expression of hemoglobin in alveolar epithelial cells.  Am J Respir Cell Mol Biol. 2011 Apr;44(4):439-47. Epub 2010 May 27.
  4. Grek CL, Newton DA, Qiu Y, Wen X, Characterization of alveolar epithelial cells cultured in semipermeable hollow fibers., Baatz JE. Characterization of alveolar epithelial cells cultured in semipermeable hollow fibers.  Exp Lung Res. 2009 Mar;35(2):155-74.
  5. Ellett JD, Evans ZP, Zhang G, Chavin KD, Spyropoulos DD. A rapid PCR-based method for the identification of ob mutant mice.  Obesity (Silver Spring). 2009 Feb;17(2):402-4. Epub 2008 Oct 23.
  6. Zhang XK, Moussa O, LaRue A, Bradshaw S, Molano I, Spyropoulos DD, Gilkeson GS, Watson DK. The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice.  J Immunol. 2008 Aug 1;181(3):1644-54.
  7. McCabe CD, Spyropoulos DD, Martin D, Moreno CS. Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer.  Cancer Res. 2008 Mar 15;68(6):1988-96.
  8. Higuchi T, Bartel FO, Masuya M, Deguchi T, Henderson KW, Li R, Muise-Helmericks RC, Kern MJ, Watson DK, Spyropoulos DD. Thymomegaly, microsplenia, and defective homeostatic proliferation of peripheral lymphocytes in p51-Ets1 isoform-specific null mice.  Mol Cell Biol. 2007 May;27(9):3353-66. Epub 2007 Mar 5.
  9. Schweinfest CW, Spyropoulos DD, Henderson KW, Kim JH, Chapman JM, Barone S, Worrell RT, Wang Z, Soleimani M. slc26a3 (dra)-deficient Mice Display Chloride-losing Diarrhea, Enhanced Colonic Proliferation, and Distinct Up-regulation of Ion Transporters in the Colon. J Biol Chem. 2006 Dec 8;281(49):37962-71. Epub 2006 Sep 25.
  10. Smith BT, Mussell JC, Fleming PA, Barth JL, Spyropoulos DD, Cooley MA, Drake CJ, Argraves WS. Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation. BMC Dev Biol. 2006 Jun 20;6:30.
  11. Burger AM, Leyland-Jones B, Banerjee K, Spyropoulos DD, Seth AK. Essential roles of IGFBP-3 and IGFBP-rP1 in breast cancer. Eur J Cancer. 2005 Jul;41(11):1515-27. Review.
  12. Mitas M, Almeida JS, Mikhitarian K, Gillanders WE, Lewin DN, Spyropoulos DD, Hoover L, Graham A, Glenn T, King P, Cole DJ, Hawes R, Reed CE, Hoffman BJ. Accurate discrimination of Barrett's esophagus and esophageal adenocarcinoma using a quantitative three-tiered algorithm and multimarker real-time reverse transcription-PCR. Clin Cancer Res. 2005 Mar 15;11(6):2205-14.
  13. Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC. Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells. J Biol Chem. 2005 Feb 11;280(6):4772-8. Epub 2004 Nov 23.
  14. Zhang XK, Gallant S, Molano I, Moussa OM, Ruiz P, Spyropoulos DD, Watson DK, Gilkeson G. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol. 2004 Nov 15;173(10):6481-9.
  15. Masuya M, Moussa O, Abe T, Deguchi T, Higuchi T, Ebihara Y, Spyropoulos DD, Watson DK, Ogawa M. Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice. Blood. 2005 Jan 1;105(1):95-102. Epub 2004 Sep 14.
  16. Maroulakou IG, Spyropoulos DD. The study of HOX gene function in hematopoietic, breast and lung carcinogenesis. Anticancer Res. 2003 May-Jun;23(3A):2101-10. Review.
  17. Spyropoulos DD, Bartel FO, Higuchi T, Deguchi T, Ogawa M, Watson DK. Marker-assisted study of genetic background and gene-targeted locus modifiers in lymphopoietic phenotypes. Anticancer Res. 2003 May-Jun;23(3A):2015-26. Review.
  18. Kawada H, Ito T, Pharr PN, Spyropoulos DD, Watson DK, Ogawa M. Related Articles Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice. Int J Hematol. 2001 Jun;73(4):463-8.
Last updated on 27-Aug-2015

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