Thomas C. Trusk

Thomas C. Trusk, Ph.D.
Research Associate Professor

Director, Josh Spruill Imaging Facility

Room 643, Basic Science Building
Office: (843) 792-3756

Email: truskt@musc.edu


BA Psychology St. Mary's College, Winona, MN 1975
MS Psychology Montana State University, Bozeman, MT 1978
PhD Biology Marquette University, Milwaukee, WI 1986
Postdoctoral work at Medical College of Wisconsin 1986-1990



Research Interests:

Development of the heart and circulatory system; light, fluorescent, confocal and video microscopy; image analysis; three-dimensional reconstruction; 3D printing; and biofabrication.

Directs the Molecular Morphology and Instrumentation Core


  1. Lockhart MM, Boukens BJ, Phelps AL, Brown CL, Toomer KA, Burns TA, Mukherjee RD, Norris RA, Trusk TC, van den Hoff MJ, Wessels A. Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction. Dev Biol. 2014, 396(1):8-18 PMID: 25300579 PMCID: PMC4252836
  2. Jia J, Richards DJ, Pollard S, Tan Y, Rodriguez J, Visconti RP, Trusk TC, Yost MJ, Yao H, Markwald RR, Mei Y. Engineering alginate as bioink for bioprinting. Acta Biomater. 2014, 10(10):4323-31 PMID: 24998183 PMCID: PMC4350909
  3. Tan Y, Richards DJ, Trusk TC, Visconti RP, Yost MJ, Kindy MS, Drake CJ, Argraves WS, Markwald RR, Mei Y. 3D printing facilitated scaffold-free tissue unit fabrication. Biofabrication. 2014, 6(2):024111 PMID: 24717646 PMCID: PMC4418504
  4. Czajka CA, Mehesz AN, Trusk TC, Yost MJ, Drake CJ. Scaffold-free tissue engineering: organization of the tissue cytoskeleton and its effects on tissue shape. Ann Biomed Eng. 2014, 42(5):1049-61 PMID: 24531747 PMCID: PMC3983990
  5. Twal WO, Klatt SC, Harikrishnan K, Gerges E, Cooley MA, Trusk TC, Zhou B, Gabr MG, Shazly T, Lessner SM, Markwald RR, Argraves WS. Cellularized microcarriers as adhesive building blocks for fabrication of tubular tissue constructs. Ann Biomed Eng. 2014, 42(7):1470-81 PMID: 23943070 PMCID: PMC3925209
  6. Damon BJ, Rémond MC, Bigelow MR, Trusk TC, Xie W, Perucchio R, Sedmera D, Denslow S, Thompson RP. Patterns of muscular strain in the embryonic heart wall. Dev Dyn. 2009, 238(6):1535-46 PMID: 19418446 PMCID: PMC2757264
  7. Wirrig EE, Snarr BS, Chintalapudi MR, O'neal JL, Phelps AL, Barth JL, Fresco VM, Kern CB, Mjaatvedt CH, Toole BP, Hoffman S, Trusk TC, Argraves WS, Wessels A. Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development. Dev Biol. 2007, 310(2):291-303 PMID: 17822691 PMCID: PMC2254939
  8. Snarr BS, Wirrig EE, Phelps AL, Trusk TC, Wessels A. A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development. Dev Dyn. 2007, 236(5):1287-94 PMID: 17265457 PMCID: PMC4003411
  9. Norris RA, Damon B, Mironov V, Kasyanov V, Ramamurthi A, Moreno-Rodriguez R, Trusk T, Potts JD, Goodwin RL, Davis J, Hoffman S, Wen X, Sugi Y, Kern CB, Mjaatvedt CH, Turner DK, Oka T, Conway SJ, Molkentin JD, Forgacs G, Markwald RR. Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem. 2007, 101(3):695-711 PMID: 17226767 PMCID: PMC3393091
  10. Mironov V, Kasyanov VA, Yost MJ, Visconti R, Twal W, Trusk T, Wen X, Ozolanta I, Kadishs A, Prestwich GD, Terracio L, Markwald RR. Cardiovascular tissue engineering I. Perfusion bioreactors: a review. J Long Term Eff Med Implants. 2006, 16(2):111-30 PMID: 16700652
  11. Drake CJ, Wessels A, Trusk T, Little CD. Elevated vascular endothelial cell growth factor affects mesocardial morphogenesis and inhibits normal heart bending. Dev Dyn. 2006, 235(1):10-8 PMID: 16170779
  12. Thompson RP, Reckova M, deAlmeida A, Bigelow MR, Stanley CP, Spruill JB, Trusk TT, Sedmera D. The oldest, toughest cells in the heart. Novartis Found Symp. 2003, 250:157-74 PMID: 12956329
  13. Wessels A, Phelps A, Trusk TC, Davis DL, Edwards AV, Burch JB, Juraszek AL. Mouse models for cardiac conduction system development. Novartis Found Symp. 2003, 250:44-59 PMID: 12956323
  14. Mironov V, Boland T, Trusk T, Forgacs G, Markwald RR. Organ printing: computer-aided jet-based 3D tissue engineering. Trends Biotechnol. 2003, 21(4):157-61 Erratum in: Trends Biotechnol 2004 Jun;22(6):265 PMID: 12679063
  15. Ogilvie RW, Blue AV, Trusk T. Computer-administered formative quizzes in a basic science course. Acad Med. 1999, 74(5):574-5 PMID: 10676188
  16. Ogilvie RW, Trusk TC, Blue AV. Students' attitudes towards computer testing in a basic science course. Med Educ. 1999, 33(11):828-31 PMID: 10583791
  17. Drake CJ, Brandt SJ, Trusk TC, Little CD. TAL1/SCL is expressed in endothelial progenitor cells/angioblasts and defines a dorsal-to-ventral gradient of vasculogenesis. Dev Biol. 1997, 192(1):17-30 PMID: 9405094
  18. Markwald R, Eisenberg C, Eisenberg L, Trusk T, Sugi Y. Epithelial-mesenchymal transformations in early avian heart development. Acta Anat (Basel). 1996, 156(3):173-86 PMID: 9124035
Last updated on 08-Nov-2016

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