- 1. To perform high quality research in biofabrication
- 2. To serve as an education/training center for developing a biofabrication workforce
- 3. To develop enabling technologies for industrial biofabrication
- 4. To promote national and international collaboration in biofabrication
Early work in 3D tissue biofabrication was spearheaded by investigators at Clemson and MUSC resulting in a number of publications (1-5). These studies lead to collaborative work between MUSC and the University of Missouri with cell spheroids and spheroid fusion. A method of printing cell aggregates was developed and patented (US 8,241,905 with additional patents pending). Organovo (San Diego CA) exclusively holds the patent rights of this methodology. These early efforts and work by scientists across South Carolina resulted in a National Science Foundation (NSF) award of $20 million over five years to build biofabrication infrastructure across the state. With this award, we have moved well beyond these early stages with more than 100 state researchers from multiple disciplines and a host of state universities contributing. Those universities include Claflin, SC State, USC, Clemson, College of Charleston and Furman. Among its many accomplishments, the program has succeeded in printing microvascular structures using living cells. These structures, measuring 100 microns by 10 millimeters, mimic the design of blood vessels of tissues.
- 1. Wilson WC, Jr. & Boland T. Cell and organ printing 1: protein and cell printers. Anat Rec A Discov Mol Cell Evol Biol 2003 272: 491-496 [PMID: 12740942].
- 2. Boland T, Mironov V, Gutowska A, Roth EA & Markwald RR. Cell and organ printing 2: fusion of cell aggregates in three-dimensional gels. Anat Rec A Discov Mol Cell Evol Biol 2003 272: 497-502 [PMID: 12740943].
- 3. Mironov V, Boland T, Trusk T, Forgacs G & Markwald RR. Organ printing: computer-aided jet-based 3D tissue engineering. Trends Biotechnol 2003 21: 157-161 [PMID: 12679063].
- 4. Mironov V. Printing technology to produce living tissue. Expert Opin Biol Ther 2003 3: 701-704 [PMID: 12880370].
- 5. Jakab K, Neagu A, Mironov V, Markwald RR & Forgacs G. Engineering biological structures of prescribed shape using self-assembling multicellular systems. Proc Natl Acad Sci U S A 2004 101: 2864-2869 [PMID: 14981244].
April 10, 2014 The paper "3D printing facilitated scaffold-free tissue unit fabrication" by Tan Y, Richards DJ, Trusk TC, Visconti RP, Yost MJ, Kindy MS, Drake CJ, Argraves WS, Markwald RR, and Mei Y was published in Biofabrication (PMID 24717646).
February 20, 2014 The SC EPSCoR/IDeA State Conference will be held at the Columbia Metropolitan Convention Center, 1101 Lincoln St., Columbia, SC on Thursday, April 24, 2014, 8:00 a.m. - 5:00 p.m. Agenda
February 15, 2014 The paper "Scaffold-Free Tissue Engineering: Organization of the Tissue Cytoskeleton and Its Effects on Tissue Shape" by Czajka CA, Mehesz AN, Trusk TC, Yost MJ, and Drake CJ was published in the Annals of Biomedical Engineering (PMID 24531747).
December, 2013 The paper "Cellularized Microcarriers as Adhesive Building Blocks for Fabrication of Tubular Tissue Constructs" by Twal WO, Klatt SC, Harikrishnan K, Gerges E, Cooley MA, Trusk TC, Zhou B, Gabr MG, Shazly T, Lessner SM, Markwald RR, and Argraves WS was selected for inclusion in a special edition on Regenerative Medicine in the Annals of Biomedical Engineering (PMID 23943070).
Thrust Leader Meeting: This meeting generally occurs every Wednesday at 3pm. The meeting is held at MUSC in Basic Science Building Room 606, and may be attended by video conference. Please contact Dr. Trusk by email (email@example.com) for details.